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In the march 2021 issue of clinical obstetrics and gynecology there are two symposia topics polycystic ovary disease the management of women with polycystic ovary disease has changed over the years but still remains difficult. Addiction is a primary chronic disease of brain reward motivation memory and related circuitry l. The drug abusing patient can provide a management dilemma for health care providers including nurses obstetrician anesthesiologist and pediatrician certain illicit drugs may mimic other diseases of pregnancy and result in inappropriate treatment for the mother and child pain management may be challenging in such patients because of . Drugs of abuse can cause changes in the brain leading to addiction current scientific focus has been on how these drugs interact with the brain and the changes they cause how those changes affect human behavior and how they may last beyond termination of drug use compulsiveness in seeking the drug impulsiveness in consuming the drug and negative affect when the drug is withheld are . March 1958 a quarterly book series volume i number 1 medical problems in pregnancy